Grapefruit Drug Interactions – Dangerous Mixing

Grapefruit with a half and leaves on white background for potential drug interactions on food list and desserts
Grapefruit can be both a blessing and a curse to diabetics. In research studies, grapefruit has been proven to give “significantly greater weight loss” in people suffering from metabolic syndrome. However, grapefruit is one of the rare fruits to dangerously interact with some pharmaceutical drugs. Naturally occurring compounds in the fruit interfere with an enzyme found in the human intestinal tract. This interaction can dramatically change the way that the drug is absorbed by the body, making it toxic. After eating grapefruit or drinking its juice, the potentially adverse grapefruit drug interactions can last up to 72 hours later. When cooking, substitute naval or blood oranges for grapefruit. (Check out our amazingly delicious grapefruit diabetic desserts!)


Always ask your pharmacist if any grapefruit drug interactions exist.

Always ask your pharmacist if any grapefruit drug interactions exist.



It is easy to check your medication to know if a potential conflict exists. Most medications for diabetics have been tested against grapefruit drug interactions.  If it is dangerous, the label will most likely have a grapefruit warning on the bottle. A good habit to form is to ask your knowledgeable pharmacist about all of your medications and grapefruit. Whenever you are prescribed a new medication it is best to ask about the grapefruit drug interactions and other potential side effects. Many complications and side effects do exist for the drugs prescribed to those suffering from Type 2 Diabetes.


Search on the internet for interactions. If you order medications online or cannot communicate easily with your pharmacist, search Google for answers. Simply enter your medication name with these terms in a Google search:

Google Search Grapefruit Interaction Medication


When new medications are released to the market, they are classified and tested against this known condition. If the medication bottle does not list anything, nor does your Google search, you should be in the clear.


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Below is a list of some, but not all, of the medications that pose a risk of toxic interaction. Double check WebMD and Wikipedia for longer lists of medications.
  • alprazolam
  • amiodarone
  • atorvastatin
  • carbamazepine
  • cilostazol
  • clarithromycin
  • colchicine
  • dronedarone
  • erythromycin
  • felodipine
  • fentanyl
  • fentanyl transdermal system
  • fexofenadine
  • indinavir
  • apremilast
  • loratadine
  • losartan
  • lovastatin
  • nilotinib
  • pazopanib
  • pimozide
  • ranolazine
  • saquinavir
  • sildenafil
  • simvastatin
  • tadalafil
  • vardenafil
  • verapamil

This list below is for the trade names of medications, which you may recognize easier than the technical classification listed above.

  • Halcion
  • Versed
  • Mogodon
  • Valium
  • Xanax
  • Doral, Dormalin
  • Norvir
  • Zoloft, Lustral
  • Dexedrine
  • Desoxyn
  • Ritalin, Concerta
  • Lipitor
  • Mevacor
  • Zocor, Simlup, Simcor, Simvacor
  • Pravachol
  • Lescol
  • Crestor
  • Cordarone
  • Multaq
  • Quinidex, Cardioquin, Quinora
  • Norpace
  • Rythmol
  • Coreg
  • Cafergot, Ergomar
  • Elavil, Endep, Vanatrip
  • Nimotop
  • Viagra
  • Cialis
  • Levitra
  • Tylenol
  • Otezla
  • Buspar
  • Codeine
  • Neoral
  • Prograf
  • Plendil
  • Cardene
  • Sular
  • Bayotensin
  • Tarceva
  • Allegra
  • Luvox, Faverin, Fevarin and Dumyrox
  • Gleevec
  • Eltroxin, Levoxyl, Synthroid
  • Cozaar
  • Losec, Prilosec
  • Seroquel
  • Prandin
  • Desyrel
  • Calan SR, Covera HS, Isoptin SR, Verelan
  • Ambien



Counting Hands for cooking hours to avoid grapefruit drug interactions in diabetic desserts.

Less Than Five Hours Of Cooking Per Week. Start your trial today!





Has this article helped you learn more about the potential grapefruit drug interactions? If you enjoyed this article, others may also find it useful. If we’ve earned it, can we kindly ask that you share this article online or through email? A referral to Five Hour Diabetic is the greatest compliment a customer can give a business and we thank you for helping us spread the good word to the millions who suffer from this troubling disease.


Diabetic Lifestyle Advocate


I am the resident Diabetic Lifestyle Advocate at Five Hour Diabetic. Here I debunk conventional thinking about nutrition & exercise. My purpose is to enable diabetics to take back control of their health. And make simple recipes that honestly don’t suck.

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